Malaria treatment may fail according to drug resistance of the infecting parasites or to bad absorption of the drug.
Le Nagard H, Vincent C, Mentré F, Le Bras J. Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. Comput Methods Programs Biomed, Epub 2010.
Kaddouri H, Nakache S, Houzé S, Mentré F, Le Bras J. Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa using Plasmodium Lactate Dehydrogenase Immunodetection Assay and inhibitory Emax model for precise IC50 measurement. Antimicrobial Agents and Chemotherapy, 2006, 50: 3343-3349.
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Without any tools we find a blurred value of IC50. Moreover we do not have confident intervals for this value. The method used in the ICEstimator function is the application of a nonlinear regression on the points. ICEstimator gives an estimated value of IC50 and its confident interval.